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目的 在西藏拉萨高原现场实验 ,观察小剂量 7 5 %NaCl和 6 0 %右旋糖酐 4 0复方溶液 (HSD)对高原失血性休克合并肺水肿大鼠的治疗作用。方法 第一部分新进高原SD大鼠 35只 ,均分 5组 :正常对照组 (n =7) ;单纯休克组 (n =7) ;休克 +肺水肿组 (n =7) ;复方高渗氯化钠—右旋糖酐组 (HSD) (n =7) ;平衡盐液组 (n =7)。维持血压 5 0mmHg ,加股静脉插管给油酸 (5 μL/10 0g体重 ) ,维持 6 0min完成模型 (正常对照组不放血不给油酸 )。分别观察给药后不同时相点的平均动脉压(MAP)、心率 (HR)、呼吸 (RR)、左室收缩压 (LVSP)、左心室压力最大上升和下降速率 (±dp/dtmax)以及动脉血气。实验结束取肺、脑测肺脑含水量 (用湿 /干重比表示 )。第二部分实验新进高原SD大鼠 36只 ,观察HSD对失血性休克合并肺水肿大鼠存活时间的影响。结果 HSD可显著升高高原失血性休克合并肺水肿大鼠平均动脉压 (MAP) ,改善其左室收缩压 (LVSP)、左心室压力最大上升和下降速率 (±dp/dtmax)及动脉血气指标 ,动物存活时间延长 ,肺脑湿 /干重比降低 ,而等容量平衡盐液无明显疗效。结论 HSD对高原创伤失血性休克合并肺水肿有较好的早期治疗作用。
Objective To investigate the therapeutic effect of 75% NaCl and 60% dextran 40 solution (HSD) on rats with hemorrhagic shock and pulmonary edema in the Tibetan Plateau. In the first part of the method, 35 SD rats were randomly divided into 5 groups: normal control group (n = 7), shock alone group (n = 7), shock plus pulmonary edema group (n = 7) Sodium-dextran group (n = 7); balanced salt group (n = 7). Maintenance of blood pressure 5 0mmHg, plus femoral vein to oleic acid (5 μL / 100g body weight), maintaining 60min to complete the model (normal control group does not give blood oleic acid). The mean arterial pressure (MAP), heart rate (HR), respiration (RR), left ventricular systolic pressure (LVSP), left ventricular pressure rise and fall rate (± dp / dtmax) Arterial blood gas. Take the lungs and brain at the end of the experiment to measure the lung water content (expressed as wet / dry weight ratio). In the second part of the experiment, 36 SD rats were randomly divided into three groups. The effects of HSD on the survival time of hemorrhagic shock combined with pulmonary edema were observed. Results HSD significantly increased mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular pressure (± dp / dtmax) and arterial blood gas index , Prolonged animal survival, lung wet / dry weight ratio decreased, while the volume of equal volume of saline no significant effect. Conclusion HSD has good early treatment effect on hemorrhagic shock with pulmonary edema on altitude sickness.