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发热伴血小板减少综合征布尼亚病毒(SFTSV)隶属于布尼亚病毒科白蛉病毒属,近年来已在中国十余省市发生了蜱叮咬感染该病毒病例,至数十人死亡。SFTSV病毒颗粒呈球形,主要分布在感染细胞的微粒体,表面有棘突,其基因组由大、中、小3个单股负链RNA片段组成,分别编码RNA聚合酶,病毒膜蛋白和非结构蛋白。感染后临床表现为发热、恶心呕吐,多数患者很快出现外周血血小板减少,肝肾等器官功能受损等症状。本文综述了新型布尼亚病毒病原学、所致疾病、感染和免疫应答以及检测的国内外研究进展,为该病毒感染的早期快速诊断、对症治疗和疾病预防等工作提供参考。
Fever with thrombocytopenia syndrome Bunyavirus (SFTSV) belongs to the genus Bunyaviridae and belongs to the genus Bunyavirus. In recent years, tick bites have infected the virus in more than 10 provinces and cities in China, killing dozens of people. SFTSV virus particles spherical, mainly in the microsomal infected cells, the surface spinous process, the genome consists of large, medium and small three single-stranded negative RNA fragments, respectively, encoding RNA polymerase, viral membrane protein and non-structural protein. Clinical manifestations of infection after fever, nausea and vomiting, the majority of patients soon appeared peripheral thrombocytopenia, liver and kidney damage and other organ dysfunction and other symptoms. This review summarizes the domestic and foreign research progress of the new Bunyavirus etiology, diseases, infections and immune responses as well as its detection, providing a reference for the early rapid diagnosis, symptomatic treatment and disease prevention of the virus infection.