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目的:探讨曲美他嗪、通心络合用对于老年顽固性心绞痛的疗效。方法:将90例老年顽固性心绞痛患者按就诊或住院顺序随机分为对照组和治疗组。对照组给予常规药物治疗(曲美他嗪、硝酸异山梨酯片、钙拮抗剂、他汀类调脂药、ACE、I肝素等),治疗组在对照组基础上加用通心络治疗,疗程12周,观察治疗前后心绞痛发作次数、心电图ST-T变化。结果:心绞痛治疗组有效率80.0%,对照组有效率57.8%,有显著性差异(χ2=4.18,P=0.021<0.05);心电图治疗组显效率28.9%,对照组显效率8.9%,有非常显著性差异(χ2=11.31,P=0.002<0.01);治疗组总有效率62.2%,对照组总有效率35.6%,有显著性差异(χ2=6.40,P=0.018<0.05)。结论:曲美他嗪、通心络联合应用于老年顽固性心绞痛患者,可显著提高心绞痛疗效,并使心电图ST-T改善。
Objective: To investigate the effect of trimetazidine and Tongxinluo combination on senile intractable angina pectoris. Methods: 90 elderly patients with refractory angina were randomly divided into control group and treatment group according to the doctor’s visit or hospitalization order. The control group was given conventional drug therapy (trimetazidine, isosorbide dinitrate tablets, calcium antagonist, statin lipid-lowering drugs, ACE, I heparin, etc.), the treatment group in the control group plus Tongxinluo treatment, treatment Twelve weeks, the number of angina attacks and ST-T changes were observed before and after treatment. Results: The effective rate of angina pectoris group was 80.0% and that of control group was 57.8% (χ2 = 4.18, P = 0.021 <0.05). The effective rate of electrocardiogram was 28.9% and that of control group was 8.9% (Χ2 = 11.31, P = 0.002 <0.01). The total effective rate was 62.2% in the treatment group and 35.6% in the control group, with significant difference (χ2 = 6.40, P = 0.018 <0.05). Conclusion: The combination of trimetazidine and Tongxinluo in elderly patients with refractory angina can significantly improve the curative effect of angina pectoris and improve ST-T of electrocardiogram.