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目的：探讨急性冠状动脉综合征患者经皮冠状动脉介入治疗前后心室肌跨壁复极离散度指标的变化。方法根据冠脉造影结果，将102例急性冠状动脉综合征患者分为经皮冠状动脉介入治疗组（研究组）67例，单纯药物治疗组（对照组）35例，分别检测治疗前后24 h内两组心电图的QT离散度、T波峰‐末间期，分析两组治疗前后校正后QT间期、T 波峰‐末间期及 T 波峰‐末间期／QT比值的变化，统计恶性心律失常发生率。结果研究组经皮冠状动脉介入治疗后心电图校正后T波峰‐末间期及T波峰‐末间期／QT比值较治疗前明显减小（P＜0．01），对照组仅校正后T波峰‐末间期较治疗前明显减小（P＜0．05）。研究组治疗前心电图 T 波峰‐末间期／QT比值显著高于对照组（P＜0．01），治疗后心电图校正后 T 波峰‐末间期明显小于对照组（P＜0．05）。研究组恶性心律失常事件发生率低于对照组。结论经皮冠状动脉介入治疗能有效改善急性冠状动脉综合征患者心室肌跨壁复极离散度，对预测恶性心律失常、心血管事件及心源性猝死具有重要意义。“,”Objective To explore the changes of ventricular muscle transmural repolarization dispersion indexes of patients with acute coronary syndrome (ACS) before and after percutaneous coronary interven‐tion (PCI) .Methods According to coronary angiography 102 ACS patients were assigned to PCI treat‐ment group (n=67 ,research group) and simple medication (n=35 ,control group) ,QT dispersion and Tpeak‐end interval (Tp‐e) within 24 hours before and after treatment detected ,changes of pre‐and post‐treatment corrected QT interval (QTc) ,Tp‐e and Tp‐e/QT ratio analyzed ,and malignant arrhythmia inci‐dences added up .Results The changes of corrected ECG Tp‐e and Tp‐e/QT ratio after PCI reduced sig‐nificantly in research group (P<0 .01) ,so did Tp‐e in control group (P<0 .05) .Tp‐e/QT ratio was sig‐nificantly higher before treatment (P<0 .01) and corrected ECG Tp‐e smaller after treatment (P<0 .05) in research than in control group .Malignant arrhythmia incidences were lower in research than in control group .Conclusion PCI could effectively improve ventricular muscle transmural repolarization dispersion and has an important significance for predicting malignant arrhythmia ,cadiovascular event and sudden car‐diac death .