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目的 探讨年龄、性别、绷带式隐形眼镜配戴、术后局部使用不同药物及手术切削深度诸因素对PRK术后角膜上皮愈合的影响。方法 对 2 5 8例实施PRK术病人 (393只眼 )进行前瞻、随机、双盲、设立安慰剂对照的临床研究。结果 不同年龄、性别、术后配戴隐形眼镜及手术切削深度诸因素对角膜上皮愈合时间无显著性差别 (P >0 0 5 )。术后使用双氯灭痛滴眼液、透明质酸钠及安慰剂组角膜上皮愈合的时间分别是 :3 78天± 1 37天、2 86天± 1 44天、3 31天± 1 5 0天 (P <0 0 5 )。结论 年龄、性别、术后配戴隐形眼镜以及手术切削深度对PRK术后角膜上皮愈合不构成影响 ,而双氯灭痛可延长角膜上皮愈合 ,透明质酸钠可促进角膜上皮的修复。
Objective To investigate the effect of various factors such as age, gender, bandage contact lens wear, postoperative local application of different drugs and surgical depth on corneal epithelial healing after PRK. Methods A prospective, randomized, double-blind, placebo-controlled clinical study of 258 PRK patients (393 eyes) undergoing PRK surgery was performed. Results There were no significant differences in the healing time of corneal epithelium between different age groups, gender, postoperative contact lens wear and surgical depth of cut (P> 0.05). Postoperative use of diclofenac eye drops, sodium hyaluronate and placebo corneal epithelial healing time were: 3 78 days ± 37 days, 2 86 days ± 1 44 days, 31 31 days ± 150 days (P <0 0 5). Conclusions Age, sex, wearing contact lenses after operation and depth of surgical resection have no effect on corneal epithelial healing after PRK. Diclofenac can prolong the healing of corneal epithelium and sodium hyaluronate can promote the repair of corneal epithelium.