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目的观察大剂量山莨菪碱(50mg/d)治疗糖尿病周围神经病变(DPN)的疗效。方法 112例DPN患者随机分为2组,治疗组应用山莨菪碱50mg/d静脉滴注,对照组20mg/d,均持续2～3周。结果治疗组显效率为68%,总有效率为88%,治疗组为32%,总有效率69.5%2组比较差异有统计学意义(P<0.05)。结论大剂量山莨菪碱50mg/d静脉滴注治疗DPN疗效明显优于20mg/d。
Objective To observe the effect of large dose of anisodamine (50mg / d) on diabetic peripheral neuropathy (DPN). Methods One hundred and twelve patients with DPN were randomly divided into two groups. The treatment group was treated with 50 mg / d anisodamine and the control group was given 20 mg / d for 2 ~ 3 weeks. Results The effective rate of treatment group was 68%, the total effective rate was 88%, the treatment group was 32%, the total effective rate was 69.5%. There was significant difference between the two groups (P <0.05). Conclusion High-dose Anisodamine 50mg / d intravenous drip treatment of DPN was significantly better than 20mg / d.