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目的检测草酸钙尿石症患者尿α1微球蛋白(α1-MG)和β2微球蛋白(β2-MG)水平,探讨α1-MG和β2-MG与草酸钙尿石症的关系。方法将2010年3月至2012年12月收治的86例尿石症患者,根据尿结石成分分为草酸钙尿石症组(45例)和非草酸钙尿石症组(41例),并以同期健康体检者45例为对照组,比较3组血、尿生化指标、微量元素及α1-MG、β2-MG水平。结果 3组患者血液生化指标比较,草酸钙、非草酸钙尿石症组肌酐(Cr)、尿素氮(BUN)均高于对照组(P均<0.05),其余指标(钙、磷、钾、钠、镁、尿酸)差异均无统计学意义(P均>0.05);3组尿液钙、磷、钾、钠、镁水平差异无统计学意义(P均>0.05);草酸钙尿石症组尿α1-MG、β2-MG水平均高于非草酸钙尿石症组和对照组(P均<0.01);非草酸钙尿石症组尿α1-MG、β2-MG水平与对照组差异均无统计学意义(P均>0.05);非草酸钙尿石症组尿酸水平高于草酸钙尿石症组和对照组(P均<0.01),草酸钙尿石症组和对照组尿酸水平差异无统计学意义(P>0.05)。结论α1-MG、β2-MG可能参与了草酸钙尿石症的形成。尿α1-MG、β2-MG水平可作为初步判断草酸钙结石的指标。
Objective To detect urinary α1-microglobulin (α1-MG) and β2-microglobulin (β2-MG) in patients with urolithiasis and investigate the relationship between α1-MG and β2-MG and urolithiasis. Methods 86 patients with urolithiasis from March 2010 to December 2012 were divided into urolithiasis group (n = 45) and non-oxalate urolithiasis group (n = 41) based on urolithiasis In the same period, 45 healthy people were taken as the control group. Blood, urine biochemical indexes, trace elements, α1-MG and β2-MG were compared among the three groups. Results Compared with the control group, creatinine (Cr) and urea nitrogen (BUN) of oxalic acid calcium and non-calcium oxalate stones in the three groups were significantly higher than those in the control group (P <0.05) Sodium, magnesium and uric acid) (P> 0.05). There was no significant difference in urinary calcium, phosphorus, potassium, sodium and magnesium levels among the three groups (P> 0.05) The levels of urinary α1-MG and β2-MG in urination group were higher than those in non-oxalic acid urolithiasis group and control group (all P <0.01). Urinary α1-MG and β2-MG levels in urinary calcium- (P> 0.05). Uric acid levels in non-oxalate urolithiasis group were higher than those in urolithiasis group and control group (all P <0.01). Uric acid levels in urolithiasis patients and control group were significantly higher than those in control group The difference was not statistically significant (P> 0.05). Conclusion α1-MG and β2-MG may be involved in the formation of urolithiasis. Urinary α1-MG, β2-MG levels can be used as an initial indicator of calcium oxalate stones.