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目的探讨藏药佐太对西红花苷-1在大鼠体内药动学特征的影响。方法对照组(连续ig生理盐水7d)和实验组(连续ig佐太混悬液7d或21d)大鼠按5mg/kg剂量im西红花苷-1后,采用反相高效液相色谱法测定给药后大鼠血浆中西红花苷-1的质量浓度,DAS2.0软件计算各组大鼠西红花苷-1的药动学参数。结果实验组大鼠分别按10mg/(kg.d)连续ig佐太7d和21d后,西红花苷-1的药动学特征发生明显变化,AUC、Cmax和MRT显著大于对照组,而CL和Vd显著小于对照组,并且随着佐太用药时间的延长,西红花苷-1的AUC增大。结论给予佐太后西红花苷-1在大鼠体内的吸收显著增多、消除显著减慢。
Objective To investigate the effects of Tibetan medicine Zuotai on the pharmacokinetics of crocin-1 in rats. METHODS: The rats in the control group (continuous ig normal saline for 7 days) and the experimental group (continuous ig scotian suspension for 7 days or 21 days) were administered with 5mg/kg dose of esculin-1 and measured by RP-HPLC. The concentration of crocin-1 in rat plasma was determined after administration. DAS2.0 software was used to calculate the pharmacokinetic parameters of crocin-1 in each group. RESULTS: The pharmacokinetics of crocin-1 was significantly changed in rats of the experimental group at 10 mg/(kg.d) for 7 days and 21 days respectively. The AUC, Cmax, and MRT were significantly greater than those in the control group. The Vd and Vd were significantly smaller than those of the control group, and the AUC of crocusid-1 was increased with the prolonged administration of Zuotai. Conclusion The absorption of Zuotaihou crocin-1 in rats was significantly increased and the elimination was significantly slowed down.