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目的:研究复方蛇床酊的抑菌、抗炎及止痒的药理作用,为其临床应用提供药效学依据。方法:采用二倍稀释法、二甲苯致小鼠耳廓肿胀法、角叉菜胶致大鼠足跖肿胀法及磷酸组织胺致痒法,观察复方蛇床酊的体外抑菌最小抑菌浓度、对动物的肿胀及致痒阈的影响。结果:复方蛇床酊对金黄色葡萄球菌、大肠埃希菌及铜绿假单胞菌均具有不同程度的抑制作用;能明显抑制小鼠耳廓肿胀和大鼠足跖肿胀;能显著提高小鼠对组胺的致痒阈。结论:复方蛇床酊具有良好的抗菌、消炎、止痒等作用。
Objective: To study the antibacterial, anti-inflammatory and anti-itch pharmacological effects of compound snake bed tincture and to provide a pharmacodynamic basis for its clinical application. Methods: Two-fold dilution method, auricle swelling induced by xylene in mice, paw edema induced by carrageenan and histamine pruritus induced itching were used to observe the antibacterial minimal inhibitory concentration , The impact of animal swelling and itching threshold. Results: The compound snake bed tincture inhibited Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa to varying extents, and significantly inhibited the auricle swelling and rat paw edema; Itch threshold for histamine. Conclusion: The compound snake bed tincture has good antibacterial, anti-inflammatory, itching and other effects.