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目前,我国每年平均约有200万新增癌症患者,其中约50%~60%的患者最终发生骨转移。骨癌及癌细胞骨转移会造成病理性骨折、恶性高钙血症、骨髓浸润、脊髓和神经压迫等多种骨相关事件,导致患者的中位生存时间仅为8~10个月。因而,深入研究癌症骨转移机制,建立癌症患者骨癌及骨转移的早期预警体系,对合理选择治疗方式预防癌细胞骨转移,提高癌症的治愈率有着重要
At present, China has an average of about 2 million new cancer patients each year, of which about 50% to 60% of patients eventually undergo bone metastases. Bone cancer and cancer cell bone metastases can cause pathological fractures, malignant hypercalcemia, bone marrow infiltration, spinal cord and nerve compression and other bone-related events, resulting in the median survival time of patients is only 8 to 10 months. Therefore, in-depth study of the mechanism of bone metastasis of cancer and establishment of early warning system for bone cancer and bone metastasis in cancer patients is important for the rational selection of treatment modalities to prevent bone metastasis of cancer cells and improve the cure rate of cancer