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目的：探讨血浆置换及联合化疗治疗活动性强直性脊柱炎（AS）的机制及疗效。方法：采用自动血浆分离器进行血浆置换与环磷酰胺、利美达松、氯甲喋呤和柳氮磺胺吡啶联合化疗相结合治疗AS。结果：治疗组的临床表现及实验室指标明显恢复，治疗组与对照组Ⅰ、Ⅱ、Ⅲ总有效率分别为97．7％，87．7％，82．22％和48．27％，治疗组与对照组比较，差异有显著性意义（P＜0．05，P＜0．001，P＜0．001）。结论：血浆置换及联合化疗治疗活动性AS，起效快，疗效高，缓解期长，而副作用无明显增加，是治疗活动性AS的一种更有效的措施。
Objective: To investigate the mechanism and effect of plasma exchange and chemotherapy in active ankylosing spondylitis (AS). METHODS: Plasma exchange was performed using an automated plasma separator in combination with cyclophosphamide, lemethasone, methotrexate, and sulfasalazine in combination with chemotherapy. Results: The clinical manifestations and laboratory parameters of the treatment group were significantly recovered. The total effective rates of the treatment group and the control group were 97.7%, 87.7%, 82.22% and 48.27%, respectively Compared with the control group, the difference was significant (P <0.05, P <0.001, P <0.001). Conclusion: Plasma exchange and combined chemotherapy is a more effective treatment for active AS, which has the advantages of rapid onset, high efficacy, long response time and no significant increase in side effects.