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目的重离子对肿瘤放疗比常规放疗更具优势,因为重离子放疗具有极佳的生物效应和剂量一致性。多房棘球蚴病具有肿瘤特性,本研究主要目的是用重离子放疗作为多房棘球蚴病的一种非手术治疗方法。方法通过LD50来评价原头蚴的死亡情况,应用光镜和投射电镜研究多房棘球蚴经X射线和碳离子电离辐射照射后形态结构变化。结果电离辐射使多房棘球蚴细胞质减少,生发层细胞深入到角质层内的绒毛消失。细胞器混乱并聚集,线粒体、高尔基复合体等细胞器大量消失,生发层细胞内出现大液泡。与X线相比,碳离子辐射对多房棘球蚴的抑制作用更为明显。结论多房棘球蚴经电离辐射后细胞结构和超微结构发生巨大变化,提示电离辐射可抑制多房棘球蚴生长。碳离子电离辐射对多房棘球蚴的抑制作用比X线辐射照射更为明显。
Objective Heavy ion radiotherapy for cancer is more advantageous than conventional radiotherapy, because of heavy ion radiotherapy with excellent biological effects and dose consistency. Multiple echinococcosis with tumor characteristics, the main purpose of this study is to use heavy ion radiation as a non-surgical treatment of multilocular echinococcosis. Methods LD50 was used to evaluate the mortality of protozoa. The morphological changes of Echinococcus multilocularis were studied by light and electron microscopy after X-ray and carbon ionizing radiation. Results Ionizing radiation decreased the cytoplasm of Echinococcus multilocularis, and the villi of germinal layer cells disappeared into the stratum corneum. Organelles confused and gathered, mitochondria, Golgi complex and other organelles disappeared in large numbers, germinal layer cells within the large vacuole. Compared with the X-ray, carbon ion radiation on the inhibition of multi-room echinococcosis more pronounced. Conclusion The cell structure and ultrastructure of Echinococcus multilocularis undergo great changes after ionizing radiation, suggesting that ionizing radiation can inhibit the growth of Echinococcus multilocularis. The inhibitory effect of ionizing radiation of carbon ion on Echinococcus multilocularis was more obvious than that of X-ray irradiation.