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用PAP法对104例胃癌手术标本进行CEA反应及预后关系的研究。结果显示:胃癌组织CEA分布及含量明显异常。随癌浸润深度增加,CEA阳性率增高,脉管浸润组和淋巴结转移组CEA阳性率明显高于无脉管浸润组及无淋巴结转移组。CEA(-)组5年生存比例明显高于CEA(+)组;在浸润或转移组中,也是CEA(-)组生存比例较CEA(+)组高。提示:CEA(+)肿瘤生物学行为较恶,有扩散和转移的倾向,组织中CEA检测对确定肿瘤浸润,转移及预后有一定价值。
The PAP method was used to study the relationship between CEA response and prognosis in 104 cases of gastric cancer. The results showed that the distribution and content of CEA in gastric cancer tissues were significantly abnormal. With the increase of the depth of invasion, the positive rate of CEA increased. The positive rate of CEA in vascular infiltration group and lymph node metastasis group was significantly higher than that in non-vessel infiltration group and no lymph node metastasis group. The 5-year survival rate of the CEA(-) group was significantly higher than that of the CEA(+) group. In the infiltration or metastasis group, the CEA(-) group had a higher proportion of survival than the CEA(+) group. It is suggested that CEA(+) tumors are more biologically aggressive and have a tendency to spread and metastasize. CEA detection in tissues may have certain value in determining tumor invasion, metastasis, and prognosis.