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目的分析PCI术后TIMI血流、TMPG分级;术后30dMACE发生率;血小板数量和出血情况。方法入院后予阿司匹林、氯吡格雷,替罗非班组(32例)于PCI术前予欣维宁负荷剂量推注,静脉泵入24~36h。结果替罗非班组增加PCI术后TIMI3级血流、TMPG3级,改善心肌微循环:减少30d心源性死亡、非致死性再梗死、靶血管再次血运重建、心绞痛等心血管事件、引起血小板减少和增加出血风险,但未见严重出血患者。结论早期应用替罗非班改善心肌微循环及减少心血管事件且具有安全性。
Objective To analyze TIMI flow, TMPG grading after PCI, the incidence of MACE 30 days after operation, the number of platelets and bleeding. Methods After admission to aspirin, clopidogrel, tirofiban group (32 cases) before PCI to Xinwening load bolus injection, intravenous infusion of 24 ~ 36h. Results Tirofiban increased the level of TIMI3 blood flow and TMPG3 level after PCI, and improved the microcirculation of myocardium. It reduced cardiovascular events such as cardiac death 30d, nonfatal reinfarction, revascularization of target vessel and angina pectoris, Reduce and increase the risk of bleeding, but no severe bleeding in patients. Conclusion Early application of tirofiban improves myocardial microcirculation and reduces cardiovascular events and is safe.