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复方甘草片中吗啡含量甚微,每片0.18毫克,《中国药典1963年版》没有规定定性的方法。用提取法提取吗啡作显色反应,结果不明显,难以证实吗啡的存在。本文介绍先用提取法提取吗啡,再将提取物进行薄层层析,用已知吗啡作对照,在荧光灯下观察,吗啡有紫色荧光,由荧光斑点的颜色、位置及再用碘铂酸钾试液显色,可检出吗啡的存在;还可进一步在紫外测定吸收曲线及最大吸收峰进行确证。(测定紫外吸收曲线如不能找出最大吸收峰,可用戊醇精制之)。方法:取本品30片,研细,加氢氧化钙
Compound licorice tablets morphine content is very small, 0.18 mg per tablet, “Chinese Pharmacopoeia 1963 Edition” does not provide for qualitative methods. Extraction of morphine for color reaction, the result is not obvious, it is difficult to confirm the presence of morphine. This article describes the first extraction of morphine extracted, and then extract thin layer chromatography, with known morphine as a control, observed under fluorescent light, morphine purple fluorescence from the fluorescent spots of color, location and reuse of potassium iodate Test solution color, the presence of morphine can be detected; can also be further measured in the UV absorption curve and the maximum absorption peak confirmation. (Determination of UV absorption curve can not find the maximum absorption peak, available pentanol refined). Methods: Take this product 30, research fine, add calcium hydroxide