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目的探讨氮氧化酶抑制剂YS310对豚鼠形觉剥夺性近视的治疗作用。设计实验性研究。研究对象豚鼠。方法3￣4周龄三色豚鼠45只,右眼不透明眼罩遮盖,左眼不遮盖,随机分为5组(每组9只):阳性对照组滴用0.1%阿托品,低、中、高浓度用药组分别滴用0.03%、0.1%、0.3%的YS310滴眼液,阴性对照组滴用YS310溶媒,均为右眼给药,每日3次,连续4周。实验前后分别用检影镜和A型超声波测眼屈光度数及眼轴长度。主要指标屈光度数、眼轴长度。结果遮盖4周后,在屈光度数方面,阴性对照组增加了-6.33D。其余各组与阴性对照组相比,阿托品组(增加-4.13D)差异有显著性意义(P=0.011);低浓度组(增加-4.97D)差异无显著性(P=0.066);中浓度组(增加-4.81D)、高浓度组(增加-4.53D)差异有显著性(P=0.041、0.017)。在眼轴方面,阴性对照组增加了0.30mm,阿托品组及低、中、高浓度用药组分别增加了0.22mm、0.29mm、0.27mm、0.26mm,与阴性对照组相比均无显著性差别(P均>0.05)。结论0.1%￣0.3%YS310对豚鼠形觉剥夺性近视的屈光改变有一定的抑制效果,但不能有效地抑制眼轴的增长。(眼科,2006,15:195-197)
Objective To investigate the therapeutic effect of nitric oxide oxidase inhibitor YS310 on shape-deprivation myopia in guinea pigs. Design experimental research. Study object guinea pigs. METHODS: Forty-five tricolor guinea pigs (3 ~ 4 weeks old) were covered with ophthalmologic ophthalmoscope in the right eye and were not covered in the left eye. They were randomly divided into 5 groups (9 in each group): the positive control group was treated with 0.1% atropine, YS310 eye drops of 0.03%, 0.1% and 0.3% were dripped in the medication group, and YS310 solvent was dripped in the negative control group, all of which were administered to the right eye three times a day for 4 weeks. Before and after the experiment with retinoscopy and A-type ultrasonic eye refractive power and axial length. The main indicators of refractive power, axial length. After 4 weeks of coverage, the negative control increased by -6.33D in terms of diopter. (P = 0.011), no significant difference (P = 0.066) between the low concentration group and the negative control group (P = 0.066), and no significant difference between the low concentration group (-4.97D) Group (increased -4.81D), high concentration group (increased -4.53D) difference was significant (P = 0.041,0.017). In the axial axis, the negative control group increased 0.30mm, atropine group and low, medium and high concentrations of drug group were increased 0.22mm, 0.29mm, 0.27mm, 0.26mm, compared with the negative control group no significant difference (P> 0.05). Conclusion 0.1% ~ 0.3% YS310 has some inhibitory effect on the refractive change of shape-deprivation myopia in guinea pigs, but it can not effectively inhibit the axial growth. (Ophthalmology, 2006,15: 195-197)