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目的探讨胃肠道间质瘤(GISTs)的临床病理学特征、诊断及鉴别诊断。方法对40例胃肠道间质瘤标本进行病理形态学观察及免疫组织化学标记,并进行随访。结果 40例GISTs中良性26例,交界性9例,恶性5例。组织学梭形细胞、上皮细胞及两者混合构成,免疫特征为CD34阳性率(78.0%)、CD117阳性率(93.0%)的弥漫强阳性表达。结论 GISTs由于较独特免疫组化表型,CD117、CD34可协助鉴别诊断。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of gastrointestinal stromal tumors (GISTs). Methods 40 cases of gastrointestinal stromal tumors were observed by histopathology and immunohistochemical markers and followed up. Results Among the 40 cases of GISTs, 26 were benign, 9 were borderline, and 5 were malignant. Histological spindle cells, epithelial cells and a combination of the two, the immune characteristics of CD34 positive (78.0%), CD117 positive (93.0%) diffuse strongly positive expression. Conclusion GISTs are more unique immunohistochemical phenotypes, and CD117 and CD34 may be helpful in differential diagnosis.