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目的观察丹参注射液、盐酸左氧氟沙星注射液分别溶于5%葡萄糖注射液中不溶性微粒随溶液pH值的改变而变化的情况。方法利用微粒分析仪测定2种注射液分别与5%葡萄糖注射液的混合溶液及混合溶液随pH值变化的微粒数。结果与5%葡萄糖注射液混合后,在pH值较低时,丹参注射液的不溶性微粒明显增加,盐酸左氧氟沙星注射液的不溶性微粒增加不明显。结论丹参注射液不宜与其他药物在同一容器中混合使用,不宜与较低pH值的葡萄糖注射液配伍;盐酸左氧氟沙星注射液可与5%葡萄糖注射液配伍使用。
Objective To observe the changes of insoluble particles in Salvia miltiorrhiza injection and Levofloxacin hydrochloride injection dissolved in 5% glucose injection with the change of solution pH value. Methods The particle number of the mixed solutions of 2 injections and 5% glucose injections and the mixed solution with pH value were measured by microparticle analyzer. Results When mixed with 5% dextrose injection, the insoluble particles in Salvia miltiorrhiza injection increased significantly when the pH value was low, while the insoluble particles did not increase obviously in levofloxacin hydrochloride injection. Conclusion Salvia miltiorrhiza injection should not be mixed with other drugs in the same container, and should not be used with lower pH glucose injection. Levofloxacin hydrochloride injection can be used in combination with 5% glucose injection.