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应用放射免疫分析法同步检测了44例肝硬化和22例对照组血浆心钠素(ANP)和醛固酮(ALD)含量。失代偿肝硬化组ANP 及ALD 含量均高于代偿组及对照组,失代偿肝硬化组血浆ANP 与ALD 水平呈正相关,表明肝硬化随着腹水的产生,代偿功能减低,则血浆ANP 和ALD 水平增加,故检测ANP 含量有可能反映肝硬化腹水的病变程度。同时失代偿肝硬化尿钠、尿钾、尿量及血白蛋白均有不同程度降低,提示限制钠盐摄入,适度输注白蛋白,应用腹水回输及首选抑制醛固酮利尿剂是治疗失代偿肝硬化的有效方法。
The levels of plasma atrial natriuretic peptide (ANP) and aldosterone (ALD) in 44 patients with cirrhosis and 22 controls were detected by radioimmunoassay. ANP and ALD levels in decompensated cirrhosis group were higher than those in compensatory group and control group. There was a positive correlation between plasma ANP and ALD level in decompensated cirrhosis group, indicating that ascites and hepatic cirrhosis with compensatory function decreased, ANP and ALD levels increased, so the detection of ANP content may reflect the degree of cirrhosis ascites lesions. At the same time decompensated cirrhosis urine sodium, urine potassium, urine output and serum albumin were reduced to varying degrees, suggesting limited sodium intake, moderate infusion of albumin, ascites transfusion and the preferred inhibition of aldosterone diuretics is the treatment of loss Compensatory cirrhosis of the effective method.