在地方性甲状腺肿(以下简称地甲肿)流行区,碘缺乏严重影响了甲状腺的机能,从而导致地甲肿和克汀病的发生。关于克汀病的发病机制围产期甲状腺机能低下学说受到重视。Fisher 等曾指出胎儿的下丘脑—垂体—甲状腺轴是独立于母体而存在的,Thilly提出在严重的地甲肿病区孕妇甲状腺功能不足很可能就是产生克汀病胎儿的重要原因。本文观察了围产期孕妇、脐血、新生儿直至青 In the endemic goiter (hereinafter referred to as g) swollen area, iodine deficiency seriously affect the thyroid function, resulting in the formation of goiter and cretinism. About the pathogenesis of cretinism hypothyroidism theory of perinatal attention. Fisher et al. Pointed out that the fetus’s hypothalamus-pituitary-thyroid axis exists independently of the mother, and Thilly suggests that hypothyroidism in pregnant women with severe glandular dementia is likely to be an important cause of cretinism in fetuses. This article observed perinatal pregnant women, umbilical cord blood, neonatal until youth