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应用酶标免疫测定法及放射免疫测定法分别测定了急性实验性脑缺血大白兔脑缺血前后血浆中β-血栓球蛋白(β-TG)、血小板因子4(PF_4)、血栓素 B_2(TXB_2)、6-酮前列腺素 F_1α(6-酮-PGF_1α)含量的变化。发现脑缺血后血浆中β-TG、PF_4及 TXB_2的含量显著升高(P<0.01),而6-酮-PGF_1α的含量无明显变化。应用中药川芎治疗能明显地抑制血浆中β-TG、PF_4及 TXB_2含量的变化(P<0.01),并使血浆中6-酮-PGF_1α的含量有所升高(P<0.05)。提示川芎能够有效地抑制脑缺血时体内血小板的激活,纠正循环血中 TXA_2-PGI_2平衡失调。
The levels of β-thromboglobulin (β-TG), platelet factor 4 (PF_4), and thromboxane B_2 in plasma of rats with cerebral ischemia after acute experimental cerebral ischemia were determined by enzyme-labelled immunoassay and radioimmunoassay. Changes of TXB_2) and 6-keto-prostaglandin F_1α (6-keto-PGF_1α) contents. The content of β-TG, PF_4 and TXB_2 in plasma was significantly increased after cerebral ischemia (P<0.01), but there was no significant change in the content of 6-keto-PGF_1α. The application of traditional Chinese medicine Chuanxiong can obviously inhibit the changes of plasma β-TG, PF_4 and TXB_2 contents (P<0.01), and increase the content of 6-keto-PGF_1α in plasma (P<0.05). It is suggested that Chuanxiong can effectively inhibit the activation of platelet in cerebral ischemia and correct the imbalance of TXA_2-PGI_2 in circulating blood.