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目的探讨幽门螺杆菌阳性消化性溃疡的药物治疗。方法选取幽门螺杆菌阳性的消化性溃疡患者,随机分为治疗组和对照组,治疗组用枸橼酸铋雷尼替丁350mg,2次/d,疗程1周;对照组用奥美拉唑20mg,2次/d,疗程1周。治疗前、后行胃镜检查并观察腹痛等临床表现。结果治疗组与对照组溃疡愈合率无统计学意义;治疗组Hp根除率、腹痛消失率较对照组高,有统计学意义。结论枸橼酸铋雷尼替丁效果好,不良反应少,值得临床推广应用。
Objective To investigate the drug treatment of Helicobacter pylori positive peptic ulcer. Methods Patients with H. pylori-positive peptic ulcer were randomly divided into treatment group and control group. The treatment group was given ranitidine bismuth citrate 350 mg twice daily for 1 week. The control group was omeprazole 20mg, 2 times / d, treatment for 1 week. Before treatment, after gastroscopy and observation of abdominal pain and other clinical manifestations. Results The healing rate of ulcer in treatment group and control group had no statistical significance. The elimination rate of Hp and abdominal pain in treatment group were higher than those in control group, with statistical significance. Conclusion Ranitidine bismuth citrate has good effect and few adverse reactions, which is worthy of clinical application.