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本文报导我们再次应用一次低剂量的二亚硝基哌嗪作为起动因子,用硫酸镍作为促动因子,进行诱发大鼠鼻咽癌的实验。将90只成年大鼠分为四组,即:二亚硝基哌嗪+镍胶组,二亚硝基哌嗪+镍水组,镍胶组和二亚硝基哌啼组。实验进行270天以后,将全部大鼠处死作病理检查。结果表明,在二亚硝基哌嗪+镍胶组的22只大鼠中,有5例发生恶性肿瘤(鼻咽原位鳞癌和早期鳞癌各1例,鼻腔未分化癌和鳞癌各1例,硬腭鳞癌1例),其它组则未见肿瘤发生。这再次表明,微量元素镍在诱发大鼠鼻咽癌中有促癌作用。 本实验还表明,肿瘤不仅发生在鼻咽,而且也发生在鼻腔和硬腭,因此,二亚硝基哌嗪不仅对鼻咽有亲合力,对鼻腔和硬腭也是有亲合力的。
This article reports that we once again applied a low dose of dinitrosopiperazine as a trigger and nickel sulfate as an activating factor to induce nasopharyngeal carcinoma in rats. Ninety-five adult rats were divided into four groups: dinitrosopiperazine + nickel glue group, dinitrosopiperazine + nickel water group, nickel gum group and dinitrosopiperazine group. After 270 days of experimentation, all rats were sacrificed for pathological examination. The results showed that 5 out of 22 rats in the dinitrosopiperazine + nickel gel group developed malignant tumors (1 case of nasopharyngeal in situ squamous cell carcinoma and 1 case of early squamous cell carcinoma, respectively, undifferentiated and squamous cell carcinoma of the nasal cavity. In 1 case, 1 case of hard orbital squamous cell carcinoma, no tumor occurred in other groups. This shows once again that trace element nickel has a cancer-promoting effect in rat nasopharyngeal carcinoma. This experiment also shows that the tumor not only occurs in the nasopharynx, but also occurs in the nasal cavity and hard palate. Therefore, the dinitrosopiperazine not only has an affinity for the nasopharyngeal, but also has an affinity for the nasal cavity and hard palate.