勃起功能障碍(ED)是指在有性交意愿的情况下阴茎持续至少3个月不能达到和(或)维持充分的勃起状态而获得满意的性生活~([1])。DM中ED患者为正常人群的3倍,且ED发生较正常人群早10~15年~([2~4])。DM阴茎组织中终末糖基化产物(AGEs)含量较正常人明显增多~([5]),应用AGEs抑制剂能改善DM大鼠勃起功能~([6])。本文对AGEs在DMED的发生、发展中 Erectile Dysfunction (ED) refers to the sexual life that a penis can not reach and / or maintain its full erection for at least 3 months at a sexual intercourse to achieve a satisfactory sexual life (1). ED patients with DM 3 times the normal population, and ED occurred earlier than the normal population 10 ~ 15 years ([2 ~ 4]). The content of terminal glycosylation products (AGEs) in DM penile tissue increased significantly compared with that in normal people ([5]). The application of AGEs inhibitors can improve the erectile function of diabetic rats (6). This article on the AGEs DMDM ​​in the occurrence, development