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肿瘤严重威胁着人类的健康和生命,对其治疗策略的研究一直是临床的一大难题。齐墩果酸(Oleanolic acid,OA)为五环三萜类化合物,具有显著的抗肿瘤作用。近年来,国内外学者对OA及其衍生物抗肿瘤作用进行了深入的研究,发现其对肝癌、乳腺癌、直肠癌等多种癌症都有很好的治疗作用,且OA及其衍生物在治疗肿瘤方面具有广谱抗瘤、不良反应小、安全性高、无耐药性等优点,因此在抗肿瘤作用方面具有广泛的应用前景和开发价值。查阅国内外相关文献,对OA及其衍生物抗肿瘤作用机制进行综述,为OA及其衍生物的进一步开发和应用提供理论基础和研究思路。
Tumor seriously threatens the health and life of human beings. The study of its therapeutic strategies has always been a major clinical problem. Oleanolic acid (OA) is a pentacyclic triterpene compound with significant anti-tumor effect. In recent years, domestic and foreign scholars conducted an in-depth study on the anti-tumor effect of OA and its derivatives and found that it has a good therapeutic effect on various cancers such as liver cancer, breast cancer and rectal cancer, and that OA and its derivatives With broad-spectrum anti-tumor treatment of cancer, adverse reactions, high safety, non-drug resistance, etc. Therefore, the anti-tumor effect has a wide range of applications and development value. Review the relevant literature at home and abroad to review the anti-tumor mechanism of OA and its derivatives, and provide theoretical basis and research ideas for the further development and application of OA and its derivatives.