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用酶联免疫斑点法（Ｅｌｉｓｐｏｔ）分别检测了２３例系统性红斑狼疮（ＳＬＥ），１８例其他结缔组织病（ＣＴＤ）患者和１９例健康对照组的外周血（ＰＢ）中神经髓鞘素、髓鞘素碱性蛋白（ＭＢＰ）和含脂质蛋白（ＰＬＰ）特异性抗体分泌细胞和ＩｇＧ、ＩｇＡ和ＩｇＭ非特异性抗体分泌细胞。结果发现ＳＬＥ和其他ＣＴＤ患者的３种特异性抗体分泌细胞均呈增高趋势，与健康对照组有非常显著的差异，ＳＬＥ患者尤为明显。临床不伴有中枢神经系统（ＣＮＳ）损害的ＳＬＥ和其他ＣＴＤ患者，也可出现ＭＢＰ和ＰＬＰ抗体分泌细胞增高，说明可能存在对ＣＮＳ髓鞘素组分的Ｂ细胞自身免疫攻击，可作为ＣＮＳ损伤的指征和神经精神性狼疮（ＮＰ－ＳＬＥ）的预报手段之一。
Enzyme-linked immunosorbent assay (Elispot) was used to detect the levels of neuromedin in peripheral blood (PB) of 23 patients with systemic lupus erythematosus (SLE), 18 patients with other connective tissue disease (CTD) and 19 healthy controls. Myelin basic protein (MBP) and lipid-containing protein (PLP) -specific antibody-secreting cells and IgG, IgA and IgM nonspecific antibody-secreting cells. The results showed that SLE and other CTD patients with three kinds of specific antibody-secreting cells showed an upward trend, and the healthy control group there is a very significant difference, especially in SLE patients. Increased MBP and PLP antibody secreting cells may also occur in patients with SLE and other CTD clinically not associated with central nervous system (CNS) compromise, indicating that there may be B cell autoimmune attacks on the CNS myelin component, which may serve as CNS lesions And neuropsychiatric lupus (NP-SLE) one of the means of forecasting.