近年来，梅毒病人逐渐增多，以二期梅毒较多。我们采用普鲁卡因青霉素治疗，开始使用80万u肌注日1次，用药当晚70％病人出现不同程度的吉海反应，后改用首次小剂量逐日递增的方法，吉海反应明显减少。现报告如下。临床资料门诊梅毒病人40例，男16例，女24例；年龄20～62岁，平? In recent years, syphilis patients gradually increased to more secondary syphilis. We use procaine penicillin treatment, began to use 800000 u intramuscular injection once a day, medication 70% of the patients showed different degrees of Jihai reaction, after the switch to the first small doses increased by daily method, Kyrgyzstan response was significantly reduced. The report is as follows. Clinical data Outpatient syphilis patients 40 cases, 16 males and 24 females; aged 20 to 62 years old,