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Sinkovics1978年回顾了人体肿瘤的免疫冶疗,当时BCG(卡介苗)是主要的免疫调节剂。以后又出现了几种有效的免疫调节剂。因此本文将专门讨论BCG、干扰素、活化淋巴细胞和其他免疫调节剂与胃肠癌的关系。 BCG、MER(BCG的甲醇提取物)和短小棒状杆菌疫苗已经在临床试验中广泛使用,这些制剂在动物和人体能非特异性地刺激细胞免疫反应。单一接种卡介苗或与化疗或放疗联合应用可以非特异性地提高介导细胞的免疫性。 基于动物研究提示在BCG/MER与放疗之间有
Sinkovics reviewed the immunotherapy of human tumors in 1978, when BCG was the main immunomodulator. Since then there have been several effective immune modulators. Therefore, this article will specifically discuss the relationship between BCG, interferon, activated lymphocytes and other immune modulators and gastrointestinal cancer. BCG, MER (methanol extract of BCG) and Corynebacterium parvum vaccines have been widely used in clinical trials. These preparations can non-specifically stimulate cellular immune responses in animals and humans. Single vaccination with BCG or in combination with chemotherapy or radiation therapy can non-specifically increase cell-mediated immunity. Based on animal research tips between BCG/MER and radiotherapy