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目的通过研究子宫内膜癌组织中P73、PCNA蛋白的表达,探讨二者与子宫内膜癌浸润转移的关系。方法采用免疫组化S-P法测定45例子宫内膜癌患者手术标本、15例正常子宫内膜、20例不典型增生子宫内膜组织中P73及PCNA蛋白的表达。结果在子宫内膜癌中,P73和PCNA表达明显增高,与正常增殖期子宫内膜和不典型增生内膜相比差异有统计学意义(P<0.05或P<0.01)。有肌层浸润者P73和PCNA的表达与无肌层浸润者差异均有统计学意义(均P<0.05)。有淋巴结转移者P73和PCNA均明显高表达。子宫内膜癌中,P73与PCNA呈正相关。结论 P73和PCNA蛋白在子宫内膜癌组织中的过度表达与子宫内膜癌的浸润转移密切相关,检测子宫内膜癌组织中P73和PCNA的表达可作为判断子宫内膜癌浸润转移情况的有用标志物。
Objective To study the relationship between the expression of P73 and PCNA protein in endometrial carcinoma and the invasion and metastasis of endometrial carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of P73 and PCNA in 45 cases of endometrial cancer patients, 15 cases of normal endometrium and 20 cases of atypical hyperplasia. Results The expression of P73 and PCNA in endometrial carcinoma was significantly higher than that in normal proliferative endometrium and atypical hyperplastic endometrium (P <0.05 or P <0.01). The expression of P73 and PCNA in patients with myometrial invasion was significantly different from those without myometrial invasion (all P <0.05). P73 and PCNA with lymph node metastasis were significantly higher expression. In endometrial carcinoma, P73 and PCNA were positively correlated. Conclusion The overexpression of P73 and PCNA protein in endometrial carcinoma is closely related to the infiltration and metastasis of endometrial carcinoma. Detecting the expression of P73 and PCNA in endometrial carcinoma can be useful as a marker of invasion and metastasis of endometrial carcinoma landmark.