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目的监测衢州市健康人群百日咳和白喉毒素抗体,评估其免疫水平。方法按机械抽样方法随机抽取新生儿、2岁~、3岁~、4岁~、6岁~、8岁~、11岁~、16岁~、26岁~、36岁~和≥60岁共11个年龄组各30~50名监测对象,采用酶联免疫法测定百日咳PT-Ig G抗体和白喉毒素Ig G抗体水平。结果百日咳PT-Ig G抗体总阳性率26.61%,平均抗体几何均数(GMC)为14.09 FDA-U/m L;阳性率和GMC均先随年龄增长而降低而后上升并维持在较高水平,各年龄组间差异均有统计学意义(P<0.01)。白喉毒素Ig G抗体阳性率100.00%,保护率为49.02%,平均GMC为0.12 IU/m L;安全保护率最高的是2~<8岁人群,GMC也相应维持较高水平,总体随着年龄增长而降低;各年龄组保护率和GMC差异均有统计学意义(P<0.01)。结论该市健康人群百日咳PT-Ig G抗体阳性率较高,白喉毒素抗体形成了较好的免疫屏障。
Objective To monitor pertussis and diphtheria toxin antibodies in healthy people in Quzhou and assess their immunity. Methods Newborns were randomly selected according to the mechanical sampling method. They were 2 years old, 3 years old, 4 years old, 6 years old, 8 years old, 11 years old, 16 years old, 26 years old, 36 years old and 60 years old Eleven age groups of 30 to 50 subjects were measured by enzyme-linked immunosorbent assay pertussis PT-Ig G antibody and diphtheria toxin Ig G antibody levels. Results The total positive rate of pertussis PT-Ig G antibody was 26.61%, the average antibody geometric mean (GMC) was 14.09 FDA-U / mL. The positive rate and GMC decreased with age and then increased and remained at a high level, The differences among all age groups were statistically significant (P <0.01). Diphtheria toxin Ig G antibody positive rate of 100.00%, the protection rate was 49.02%, the average GMC was 0.12 IU / m L; the highest safety protection rate is 2-8 years old population, GMC also maintained a high level, with the overall age Increase and decrease; The protection rate and GMC difference in all age groups were statistically significant (P <0.01). Conclusion The positive rate of pertussis PT-Ig G antibody in healthy people in this city is high, and the diphtheria toxin antibody forms a good immune barrier.