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[目的]通过对尘肺病并发心力衰竭患者中骨桥蛋白(osteopontin,OPN)水平测定,分析OPN的临床意义。[方法]入选健康人群38人(对照组)、尘肺病患者25人(单纯尘肺病组)、尘肺病并发心力衰竭患者(尘肺病并发心力衰竭组)20人,分别测定三组血液生化指标和OPN水平,对结果进行统计学分析。[结果]尘肺病并发心力衰竭组血浆N末端B型利钠肽原(NT-proBNP)水平明显高于对照组及单纯尘肺病组,单纯尘肺病组、尘肺病并发心力衰竭组的WBC、超敏C反应蛋白(hs-CRP)高于对照组,差异均有统计学意义(P<0.01)。对照组、单纯尘肺病组、尘肺病并发心力衰竭组中OPN水平分别为(71.3±15.3)ng/mL、(145.3±24.9)ng/mL、(199.4±25.2)ng/mL,尘肺病并发心力衰竭组高于对照组及尘肺病组(P<0.01)。[结论]OPN可能参与了尘肺病并发心力衰竭的病理、生理过程,有望成为尘肺病并发心力衰竭早期血清学标志之一。
[Objective] To analyze the clinical significance of osteopontin (OPN) in patients with pneumoconiosis complicated with heart failure. [Methods] Totally 38 healthy people (control group), 25 pneumoconiosis patients (simple pneumoconiosis group) and 20 pneumoconiosis patients (pneumoconiosis complicated with heart failure group) were enrolled. Blood biochemical indexes and OPN levels, the results of a statistical analysis. [Results] The plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with pneumoconiosis complicated with heart failure were significantly higher than those in patients with simple pneumoconiosis, pneumoconiosis alone, and pneumoconiosis patients with heart failure Sensitive C-reactive protein (hs-CRP) higher than the control group, the difference was statistically significant (P <0.01). The levels of OPN in control group, pure pneumoconiosis group and pneumoconiosis complicated with heart failure group were (71.3 ± 15.3) ng / mL, (145.3 ± 24.9) ng / mL and (199.4 ± 25.2) ng / The failure group was higher than the control group and pneumoconiosis group (P <0.01). [Conclusion] OPN may be involved in the pathogenesis and pathophysiology of pneumoconiosis complicated with heart failure. It is expected to become one of the early serological markers of pneumoconiosis complicated with heart failure.