新生儿肺结缔组织病主要为支气管肺发育不良症(broncho pulmonary dysplasia,BPD)。近年来,在使极小未成熟儿、超未成熟儿抢救成活率提高的同时,本病已成为引起人们特别关注的人工通气疗法的副作用之一。最初,曾被认为是继发于未成熟儿呼吸窘迫综合征(RDS)的特有疾病。经临床多方验证与动物实验研究,现认为本病是“在对新生儿因某种原因引起的呼吸障碍进行一定时间的高浓度吸氧或人工通气疗法时所产生的慢性肺病变”。以下对包括定义在内的疾病概念的变化,肺纤维增殖症的病理、病因和治疗的最近见解作一简述。一、BPD 疾病概念的变迁1967年 Northway 等将患 RDS 的未成熟新生儿因应用高浓度氧人工通气疗法而产生的肺 Neonatal pulmonary connective tissue disease is mainly broncho-pulmonary dysplasia (BPD). In recent years, the immature children, ultra-immature children in the survival rate of the same time, the disease has become one of the side effects caused by special attention artificial ventilation therapy. Originally, it was thought to be a unique disease secondary to respiratory distress syndrome (RDS) in immature infants. The clinical multi-factor verification and animal experiments, the disease is now considered to be “in neonatal respiratory failure caused by some reason for a certain period of high concentrations of oxygen or artificial ventilation when the chronic lung disease.” The following is a brief overview of recent changes in the concept of disease, including definitions, pathologies, causes and treatment of pulmonary fibroplasia. First, the concept of BPD changes in the disease In 1967 Northway, etc. will be suffering from RDS in immature infants with high oxygen exposure due to artificial ventilation lungs