论文部分内容阅读
目的分析大肠癌DNA倍体含量与临床病理学特征间的关系。方法用流式细胞术进行DNA倍体含量测定,分析其变化与患者性别、年龄、肿瘤的解剖部位,淋巴结转移、分化程度的关系。结果大肠癌DNA倍体类型与患者的性别、年龄无明显的关系(p>0.05),远端大肠、有淋巴结转移及分化程度低的肿瘤异倍体发生率比近端大肠、无淋巴结转移及分化程度高的大肠癌更多见(p<0.05)。结论DNA倍体分析可为分析肿瘤是否扩散,治疗方案的选择及预后判断提供客观可靠的依据。
Objective To analyze the relationship between DNA ploidy and clinicopathological features in colorectal cancer. Methods DNA ploidy assay was performed by flow cytometry. The relationship between the change and patient’s gender, age, anatomic site of tumor, lymph node metastasis and differentiation was analyzed. Results The DNA ploidy type of colorectal cancer had no significant relationship with the sex and age of patients (p> 0.05). The incidence of aneuploidy in distal colorectal cancer with lymph node metastasis and low differentiation was higher than those in proximal colorectal cancer without lymph node metastasis More differentiated colorectal cancer is more common (p <0.05). Conclusion DNA ploidy analysis can provide an objective and reliable basis for the analysis of tumor proliferation, treatment options and prognosis.