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目的观察不同时间使用阿霉素和顺铂进行化疗的治疗效果和毒副反应。方法将本院从2008年9月~2013年10月间收治的需要使用阿霉素和顺铂进行化疗的肿瘤患者共70例,随机分为两个组,对照组和治疗组各35例,分别在不同时间给予药物,观察其治疗效果和不良反应。结果治疗组总有效率为57.1%,对照组总有效率为51.4%,两组比较差异无统计学意义(P>0.05);治疗组不良反应发生率明显小于对照组,且差异显著(P<0.01),有统计学意义。结论应用时辰药理学原理,采用固定时间给予抗癌药物治疗肿瘤,不仅不影响药物疗效,可使药物的不良反应降至最小,从而减少患者的痛苦,提高患者的耐受性,值得在临床上推广使用。
Objective To observe the therapeutic effects and side effects of chemotherapy with doxorubicin and cisplatin at different times. Methods A total of 70 cancer patients treated with doxorubicin and cisplatin in our hospital from September 2008 to October 2013 were randomly divided into two groups, 35 cases in the control group and the treatment group, Drugs were given at different times to observe the treatment effect and adverse reactions. Results The total effective rate was 57.1% in the treatment group and 51.4% in the control group, with no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P < 0.01), with statistical significance. Conclusion The application of chronological pharmacology, the use of fixed-time anticancer drugs to treat cancer, not only does not affect the drug efficacy, adverse drug reactions can be minimized, thus reducing the patient’s pain and improve patient tolerance, it is clinically Promote use.