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目的探讨尿微量白蛋白(尿mALB)与妊娠期高血压疾病患者早期肾损害的关系,评价临床诊断价值。方法采用免疫散射比浊法检测60例孕25～42周孕妇尿微量白蛋白(尿蛋白定性均为阴性),其中30例妊娠期高血压孕妇作为观察组,另30例正常孕妇为对照组。结果观察组尿微量白蛋白(26.01±7.28)mg/L,超过参考值阳性率60.00%。对照组尿微量白蛋白(8.17±2.98)mg/L,超过参考值阳性率10.00%。两组比较有统计学差异(P<0.05)。结论妊娠期高血压疾病早期肾损伤患者尿微量白蛋白明显升高,检测尿微量白蛋白可用于及早发现妊娠期高血压疾病的早期肾损伤,对及时干预,阻止病情发展有其重要的临床意义。
Objective To investigate the relationship between urinary microalbuminuria (MALB) and early renal damage in patients with hypertensive disorder complicating pregnancy and evaluate the value of clinical diagnosis. Methods Immunohistochemical turbidimetry was used to detect urine microalbuminuria in 60 pregnant women with gestational age from 25 to 42 weeks (urine protein qualitative was negative), 30 pregnant women with gestational hypertension as observation group and 30 normal pregnant women as control group. Results Urine microalbuminuria (26.01 ± 7.28) mg / L in the observation group exceeded the reference value by 60.00%. Urine microalbumin in control group (8.17 ± 2.98) mg / L, exceeding the reference value of the positive rate of 10.00%. There was a significant difference between the two groups (P <0.05). Conclusions Urine microalbuminuria in patients with early renal injury of hypertensive disorder complicating pregnancy is obviously increased. Detection of urine microalbumin can be used to detect early renal injury of hypertensive disorder complicating pregnancy. It has an important clinical significance for prompt intervention and prevention of disease progression .