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目的总结肌萎缩性侧索硬化症(ALS)的临床特点。方法对49例ALS患者的临床资料进行回顾性分析。结果ALS平均发病年龄为49.0岁;男女比例为2.1:1;肌无力、肌肉萎缩是其最早和最常见症状;其中发生在单侧上肢者24例,双上肢者3例,单侧下肢者9例,双下肢者3例,偏侧1例,双上、下肢1例,球部8例。肌电图与MRI对诊断有重要意义;49例中误诊46例,误诊率为93.9%。结论ALS多为中年发病,男性多于女性,肌电图和MRI对诊断和鉴别诊断有重要意义。
Objective To summarize the clinical features of amyotrophic lateral sclerosis (ALS). Methods The clinical data of 49 patients with ALS were analyzed retrospectively. Results The average age of onset of ALS was 49.0 years. The ratio of male to female was 2.1: 1. Muscle weakness and muscle atrophy were the earliest and most common symptoms. Among them, 24 cases were unilateral upper limbs, 3 cases were double upper limbs, 9 were unilateral lower limbs For example, 3 cases of double lower extremity, 1 case of unilateral, double upper and lower limb in 1 case, ball in 8 cases. Electromyography and MRI are of great significance in the diagnosis; 46 cases were misdiagnosed in 46 cases, the rate of misdiagnosis was 93.9%. Conclusions ALS is mostly middle age, more men than women. EMG and MRI are important for the diagnosis and differential diagnosis.