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本文研究了小鼠经~(60)Co-γ射线照射后脾脏的组织学改变及三七的保护作用。照射后第18～35天,脾脏中央动脉周围淋巴鞘的淋巴细胞明显减少,核膜崩解,胞浆空化,线粒体呈空泡状,细胞坏死;脾小结消失,免疫母细胞极少或缺如。照射后若给予小鼠三七,则在照射后第18天可见中央动脉周围淋巴鞘的淋巴细胞增多,电镜结构正常,脾小结明显并出现生发中心;照射后第35天,脾脏结构基本恢复正常,免疫母细胞的细胞器体密度明显增高,表明三七能促进损伤后的脾脏淋巴细胞增生,具有抗辐射作用。
In this study, the spleen histological changes and protective effects of Panax notoginseng were studied after irradiation with 60Co-γ rays in mice. On the 18th to 35th day after irradiation, lymphocytes in the lymphatic sheath around the central artery of the spleen decreased significantly, the nuclear membrane disintegrated, the cytoplasm cavitation, the mitochondria vacuolization, cell necrosis; the spleen nodules disappeared, and the immune mother cells were rare or absent. Such as. If mice are given Sanqi after irradiation, lymphocytes around the central arterial lymphatic sheath can be seen on the 18th day after irradiation. The structure of the electron microscope is normal, splenic nodules are obvious, and germinal centers appear; on the 35th day after irradiation, the spleen structure basically returns to normal. The density of the organelles of the immune mother cells was significantly increased, indicating that Panax notoginseng can promote splenic lymphocyte proliferation after injury and has anti-radiation effect.