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目的 对中枢神经细胞瘤进行组织学及免疫组织化学研究 ,探讨细胞分化、组织发生及增殖潜能。方法 对 37例中枢神经细胞瘤进行HE染色及 6种抗体的免疫组织化学染色 ,光镜下观察。结果 血管增生 19例 ,坏死 6例 ,出血 2 7例 ,核分裂 2 3例 ,2 5例可找到神经元 ;Synaptophysin和NSE37例阳性 ,GFAP10例偶见细胞及纤维阳性 ,ChromograininA和NF全部阴性 ,PCNA LI1 95±1 77,从 0到 9 95 %。结论 神经细胞具有进一步分化为神经元和胶质细胞的能力 ;肿瘤可能来源于胚胎残余原始神经上皮细胞 ;核分裂阴性病例的PCNA LI<1% ,核分裂阳性的病例 (除 2例外 )PC NA LI>1% ,P =0 0 0 0 0 0 8,提示核分裂阳性的中枢神经细胞瘤较核分裂阴性肿瘤增殖倾向活跃。
Objective To study the histological and immunohistochemical studies of CNS tumors and explore the cell differentiation, tissue formation and proliferation potential. Methods 37 cases of central nerve cell tumors were stained with HE and immunohistochemically stained with six antibodies. Observed under light microscope. Results There were 19 cases of angiogenesis, 6 cases of necrosis, 27 cases of hemorrhage, 23 cases of nuclear fission, 25 cases of neurons could be found; 37 cases of Synaptophysin and NSE were positive, 10 cases of GFAP were occasionally positive for cells and fibers, and Chromograinin A and NF were all negative. PCNA LI1 95±1 77, from 0 to 9 95%. Conclusion The nerve cells have the ability to further differentiate into neurons and glial cells; the tumor may originate from embryonic remnant primitive neuroepithelial cells; the PCNA LI <1% of cases with negative mitoses, and the case of positive mitosis (except 2 cases). PC NA LI > 1%, P =0 0 0 0 0 0 8, suggesting that the nuclear fibroblast-positive CNS tumor is more proliferative than the mitotic-negative tumor.