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目的 探讨MMP9和CD44V6在大肠癌中的表达与大肠腺癌术后是否复发的关系。方法 应用免疫组化技术 ,检测 12 8例大肠腺癌组织中MMP9和CD44V6的表达。结果 12 8例大肠腺癌中MMP9、CD44V6表达的阳性标记与大肠腺癌分级、浆膜浸润、淋巴结转移有相关性。结论 MMP9和CD44V6联合表达与大肠腺癌浸润转移密切相关。检测MMP9和CD44V6表达可作为判断大肠腺癌预后的客观指标。
Objective To investigate the relationship between the expression of MMP9 and CD44V6 in colorectal carcinoma and recurrence of colorectal adenocarcinoma. Methods Immunohistochemistry was used to detect the expression of MMP9 and CD44V6 in 12 8 cases of colorectal adenocarcinoma. Results The positive expression of MMP9 and CD44V6 in 12 of 8 cases of colorectal adenocarcinoma was correlated with the classification of colon adenocarcinoma, serosal invasion and lymph node metastasis. Conclusion The co-expression of MMP9 and CD44V6 is closely related to invasion and metastasis of colorectal adenocarcinoma. Detection of MMP9 and CD44V6 expression can be used as an objective indicator of the prognosis of colorectal adenocarcinoma.