论文部分内容阅读
目的设计合成2-咪唑基-戊-1,4-二烯-3-酮类衍生物,并进行抗菌活性测试。方法以不同取代的苯甲醛为起始原料,经过Aldol缩合、溴代、亲核取代和Knoevenagel缩合四步反应合成目标化合物;采用微量稀释法测定化合物最低抑菌浓度(MIC)值。结果合成了30个未见文献报道的新化合物,其结构均经1H-NMR、MS谱测定。结论目标化合物均表现出一定的抗菌活性,可作为先导化合物做进一步改造和修饰。
Aim To design and synthesize 2-imidazolyl-penta-1,4-dien-3-one derivatives and to test the antibacterial activity. Methods Different substituted benzaldehydes were used as starting materials to synthesize the target compounds through Aldol condensation, bromination, nucleophilic substitution and Knoevenagel condensation. The minimum inhibitory concentration (MIC) of compounds was determined by the method of microdilution. Results Thirty new compounds were synthesized and their structures were confirmed by 1H-NMR and MS spectra. Conclusion The target compounds all showed some antibacterial activity and could be further modified and modified as lead compounds.