碳青霉烯酶(carbapenem ases)是指能够明显水解亚胺培南或美罗培南的一类β-内酰胺酶,它包括AMBLER分子分类的A、B和D三类酶。其中,B类为金属酶,属于BUSH功能分类的3群;A、D类为丝氨酸酶,分别属于BUSH分类的2 f和2d亚群[1,2]。本文主要针对D类碳青霉烯酶的发现与分群、生化特性 Carbapenem ases refers to a class of β-lactamases that can significantly hydrolyze imipenem or meropenem and include the three classes A, B and D of the AMBLER molecule. Among them, B is a metalloenzyme belonging to 3 groups of BUSH functional classification; A and D classes are serine enzymes belonging to 2f and 2d sub-groups of BUSH classification respectively [1,2]. This article is mainly directed against the discovery, clustering and biochemical characteristics of class D carbapenemases