论文部分内容阅读
有人认为妊娠期原有癫痫发作加剧,可能是以前的足量抗惊厥药物治疗作用减低的缘故。为了探讨这种可能性作者对11例未经选择的癫痫妇女,于妊娠期和产褥期测定了抗惊厥药物苯妥英钠和/或苯巴比妥的血浆浓度。她们年龄在21～39岁之间,均系第一次或第二次妊娠,除1例妊娠毒血症和1例轻度毒血症外,其余无产科并发症。11例中,10例常规服用苯妥英钠,9例妊娠末期同妊娠初期或妊娠前比较,血浆苯妥英钠水平下降,这个结果在统计学上有显著性(P=
Some people think that the original seizure during pregnancy aggravate, may be the reason for the reduction in the role of adequate anti-convulsive drugs. To explore this possibility, the authors tested the plasma concentrations of the anti-convulsant phenytoin sodium and / or phenobarbital during pregnancy and puerperium for 11 unselected women with epilepsy. They were between the ages of 21 and 39 years, both on the first or second pregnancy, with the exception of one case of pregnancy-induced toxemia and one case of mild toxemia, with no obstetric complications. Of the 11 patients, 10 were routinely given phenytoin, and 9 had a decreased plasma phenytoin sodium level at the end of gestation compared with the first trimester or before pregnancy, a statistically significant result (P =