目的　研究分析系统性红斑狼疮 (SL E)合并中枢神经系统隐球菌感染的特点、诊断和治疗 ,以提高对本病的认识和诊治水平。方法　对 7例 SL E合并隐球菌脑膜炎 (隐脑 )病例的临床表现、脑脊液 (CSF)变化和诊治经过 ,进行回顾性总结。结果　隐脑多于 SL E患者应用大剂量肾上腺糖皮质激素时出现 ,起病隐匿 ,进展慢 ,临床及 CSF系列生化检查呈非特异 ,易误诊为狼疮脑病或结核性脑膜炎。CSF真菌培养或涂片镜检发现隐球菌是确诊的关键。对以两性霉素 B为主的抗真菌治疗反应较好 ,有效率 10 0 %。结论　早期诊断和有效抗隐球菌治疗可显著改善 SL E合并隐脑患者的预后 Objective To study the characteristics, diagnosis and treatment of central nervous system cryptococcosis complicated with systemic lupus erythematosus (SL E) in order to improve the understanding and diagnosis and treatment of this disease. Methods The clinical manifestations, changes of cerebrospinal fluid (CSF) and diagnosis and treatment of 7 cases of cryptococcal meningitis complicated with cryptococcosis were retrospectively reviewed. Results Hidden implicit more than SL E patients with high doses of glucocorticoid appear when occult onset, slow progress, clinical and CSF biochemical tests showed non-specific, easily misdiagnosed as lupus encephalopathy or tuberculous meningitis. CSF fungal culture or smear microscopy found cryptococcal diagnosis is the key. Fungi treatment of amphotericin B-based response is better, with an efficiency of 10%. Conclusions Early diagnosis and effective anti-cryptococcal therapy can significantly improve the prognosis