糖尿病的慢性并发症遍及全身各重要器官,包括大血管病变和微血管病变,其中大血管病主要包括心、脑血管及周围血管疾病,是引起患者致残、致死的主要原因之一,在糖尿病死亡原因中,动脉粥样硬化约占80%。新近研究发现,CD40与CD40L是一对互补跨膜糖蛋白,是新的炎症标志物,CD40L可通过与血管内皮细胞、平滑肌细胞、巨噬细胞表达的CD40相互作用,产生一系列的生物学效应,促进动脉粥样 Chronic complications of diabetes throughout the body of all major organs, including macrovascular disease and microvascular disease, including major vascular disease, including heart, cerebrovascular and peripheral vascular disease is caused by one of the major causes of disability and death in patients with diabetes, death Cause, atherosclerosis accounts for about 80%. Recent studies have found that CD40 and CD40L are a pair of complementary transmembrane glycoproteins and are new inflammatory markers. CD40L can interact with CD40 expressed by vascular endothelial cells, smooth muscle cells and macrophages to produce a series of biological effects , Promote atherosclerosis