对Ｐｄ／Ｃ及Ｐｄ－Ｂｉ／Ｃ催化剂的制备方法及空气氧化葡萄糖制葡萄糖酸钠进行了研究。试验结果表明，Ｐｄ－Ｂｉ共浸方法制备的催化剂活性最好。在５０～５５℃、ｐＨ９～１０、葡萄糖浓度为１０％～２０％时，使用Ｐｄ－Ｂｉ／Ｃ催化剂反应２．５ｈ转化率为９７％，选择性达９９％以上；与此相比，使用Ｐｄ／Ｃ催化剂则需要４．５ｈ才达到此转化率。在反应过程中，发现在反应速率与时间关系中，存在着“振荡”现象，此现象是由于Ｐｄ－Ｂｉ／Ｃ催化剂具有高活性，从而强烈吸咐氧而产生的自身中毒和解毒所造成，本文对此现象进行了理论探讨。 Preparation of Pd / C and Pd-Bi / C catalysts and sodium gluconate produced by air oxidation of glucose were studied. The experimental results show that Pd-Bi co-impregnation method prepared the best catalyst activity. At 50-55 ℃, pH9-10 and glucose concentration of 10% -20%, the conversion of Pd-Bi / C catalyst was 97% for 2.5h, and the selectivity was over 99%. In contrast, The Pd / C catalyst then takes 4.5 h to reach this conversion. During the reaction, it was found that there was “oscillation” in the relationship between the reaction rate and the time. This phenomenon was caused by self-poisoning and detoxification due to the high activity of the Pd-Bi / C catalyst, which strongly adsorbed oxygen. This article has carried on the theory discussion to this phenomenon.