The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoem-bolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with hu-mans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-emboliza-tion imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.