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目的:探讨原发性肝癌患者外周血中CD27和CD27L的含量及其临床意义。方法:采用ELISA法检测38例肝癌患者和40例健康查体者外周血中CD27及CD27L蛋白的含量,并分析两者与病理类型和临床分期的关系。结果:与健康查体组相比,肝癌患者外周血中CD27蛋白含量未检测到明显变化(t=1.760,P=0.082),但CD27L蛋白含量显著升高(t=39.982,P<0.001)。Spearman秩相关分析表明CD27和CD27L之间无显著相关性(rs=0.305,P=0.084)。CD27在不同病理类型和不同病理分期的肝癌患者血清中的含量无统计学差异(P>0.05);CD27L蛋白含量在III期和发生淋巴结转移的患者中显著升高(P<0.05)。结论:CD27/CD27L通路与肝癌的恶性进展和淋巴结转移有密切关系。
Objective: To investigate the content of CD27 and CD27L in peripheral blood of patients with primary liver cancer and its clinical significance. Methods: The levels of CD27 and CD27L in 38 patients with hepatocellular carcinoma and 40 healthy individuals were detected by ELISA. The relationship between them and pathological type and clinical stage was analyzed. Results: There was no significant change in the level of CD27 protein in peripheral blood of patients with liver cancer (t = 1.760, P = 0.082), but the content of CD27L protein was significantly increased (t = 39.982, P <0.001). Spearman rank correlation analysis showed no significant correlation between CD27 and CD27L (rs = 0.305, P = 0.084). There was no significant difference in the serum levels of CD27 between patients with different pathological types and histopathological stages (P> 0.05). The level of CD27L protein in patients with stage III and lymph node metastasis was significantly higher (P <0.05). Conclusion: The CD27 / CD27L pathway is closely related to the malignant progression of liver cancer and lymph node metastasis.