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目的 :观察乐卡地平对心肌梗死大鼠心肌重构的影响。方法 :雄性Wistar大鼠 ,结扎冠状动脉左前降支 ,造成心肌梗死。实验分为 4组 :假手术组、心肌梗死模型组、卡托普利组、乐卡地平组。在结扎冠状动脉后 3h开始 ,分别灌胃给予生理盐水、生理盐水、卡托普利 5 0mg·kg- 1和乐卡地平 2 .5mg·kg- 1,qd ,共 35d。给药容积均为 10mL·kg- 1。最后一次给药后 2 4h ,处死大鼠取心脏 ,测定全心重量和体重比 (THW /BW )、梗死范围 (IS)、左心室内径 (LVD)、室间隔厚度 (ST) ,用天狼猩红染色 ,在图像分析系统下测量心肌间质胶原容积系数 (ICVF)和血管周围胶原容积系数 (PCVF)。结果 :心肌梗死模型组大鼠的THW /BW [(0 .38±s 0 .0 3) % ]和LVD [(8.8± 1.4 )mm ]均显著比假手术组[(0 .32 5± 0 .0 16 ) % ;(6 .5± 0 .3)mm ]大 (P <0 .0 5 ,P <0 .0 1) ,ST[(1.71± 0 .2 2 )mm ]则明显比假手术组 [(2 .75± 0 .18)mm ]小 (P <0 .0 1) ,IS为(2 6± 3) %。与模型组比较 ,卡托普利和乐卡地平组大鼠的IS[(18± 6 ) % ,(19± 7) % ]和LVD[(7.5±0 .8)mm ,(7.7± 0 .9)mm]显著变小 (P <0 .0 5 ,P <0 .0 1) ;ST[(2 .4± 0 .4 )mm ,(2 .4± 0 .5 )mm]显著变大 (P <0 .0 5 ,P <0 .0 1)。心肌梗死模型组大鼠心肌ICVF和PCVF?
Objective: To observe the effect of lercanidipine on myocardial remodeling in myocardial infarction rats. Methods: Male Wistar rats, ligation of left anterior descending coronary artery, causing myocardial infarction. The experiment was divided into 4 groups: sham operation group, myocardial infarction model group, captopril group, lercanidipine group. At 3h after ligation of the coronary arteries, normal saline, saline, captopril 50mg · kg-1 and lercanidipine 2.5mg · kg-1, qd were administered orally for 35 days respectively. Administration volume was 10mL · kg-1. Twenty-four hours after the last administration, the heart was sacrificed and the total heart rate and body weight ratio (THW / BW), infarct size (IS), left ventricular diameter (LVD) and ventricular septum thickness (ST) Scarlet staining was used to measure myocardial interstitial collagen volume fraction (ICVF) and perivascular collagen volume fraction (PCVF) under an image analysis system. Results: THW / BW [(0.38 ± s0.03)%] and LVD [(8.8 ± 1.4) mm] in MI group were significantly higher than those in sham group [(0 .32 ± 0 ± 0) (P <0.05, P <0.01), ST [(1.71 ± 0.22) mm] was significantly higher than that of the control group The operative group [(2.75 ± 0.18) mm] was smaller (P <0.01) and the IS was (26 ± 3)%. Compared with the model group, IS [(18 ± 6)%, (19 ± 7)%] and LVD [(7.5 ± 0.8) mm, (7.7 ± 0.9) ) mm] was significantly smaller (P <0.05, P <0.01); ST [(2.4 ± 0.4mm), (2.4 ± 0.5mm) P <0. 05, P <0. 01). Myocardial infarction model rats myocardial ICVF and PCVF?