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血管生成素(angiopoietins,Angs)/Tie系统作为血管特定的配体/受体系统控制内皮细胞的存活和血管成熟。研究Angs/Tie系统有助于更好地了解该血管信号系统作为肿瘤和非肿瘤性疾病治疗靶点的作用机制。本文将对Angs在血管生成中的作用作一综述。Angs配体和Tie受体的结构及表达一、Ang-1、Ang-2的结构和表达Angs家族在20世纪90年代中期被鉴定出,其为血管
Angiopoietins (Angs) / Tie system controls endothelial cell survival and vascular maturation as a vascular specific ligand / receptor system. Studying the Angs / Tie system helps to better understand the mechanism of action of this vascular signaling system as a therapeutic target for both oncological and non-oncological diseases. This article reviews the role of Angs in angiogenesis. Structure and Expression of Angs Ligand and Tie Receptor I. Structure and Expression of Ang-1, Ang-2 The Angs family was identified in the mid-1990s as the vascular