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信号转导和转录激活因子3(STAT3)是细胞因子和生长因子受体信号的下游基因,不仅参与人体的正常生理过程,而且与肿瘤的生长、转移、浸润有关。研究发现,STAT3受到维甲酸-干扰素诱导的死亡相关基因19(GRIM-19),SOCS3,PTEN和PIAS3等基因的调控,其调控基因的异常表达将引起STAT3的持续激活和表达升高,导致肿瘤的发生、发展。在卵巢癌的发病机制中STAT3信号转导通路的持续性激活至关重要,其激活并且有基质金属蛋白酶类、Bcl-2家族成员、血管内皮生长因子、Her2基因的参与,在肿瘤的细胞抗凋亡、血管重建、浸润转移、药物耐药等过程中起重要作用,为卵巢癌免疫治疗方面提供新策略。
Signal Transducer and Activator of Transcription 3 (STAT3) is a downstream gene for cytokine and growth factor receptor signaling. It is not only involved in the normal physiological processes of the human body but also related to tumor growth, metastasis and invasion. STAT3 is regulated by retinoic acid-interferon-induced death-associated gene 19 (GRIM-19), SOCS3, PTEN and PIAS3. The abnormal expression of STAT3 will result in the sustained activation and increased expression of STAT3, leading to Tumor occurrence and development. The persistent activation of the STAT3 signal transduction pathway is crucial in the pathogenesis of ovarian cancer and its activation is mediated by the involvement of matrix metalloproteinases, Bcl-2 family members, vascular endothelial growth factor, and Her2 genes, Apoptosis, revascularization, invasion and metastasis, drug resistance and other processes play an important role in the provision of new strategies for the immunotherapy of ovarian cancer.